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Medicines > routes: transdermal & onset: Cognitive effect emerges gradually over weeks to months; ceiling effect at the therapeutic dose

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generic:
Donepezil (1)
brand:
Aricept (oral), Adlarity (transdermal patch) (1)
classes:
[[:Category:Acetylcholinesterase inhibitors|Acetylcholinesterase inhibitor]] (1) · [[:Category:Anti-dementia medicines|Anti-dementia medicine]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000017-QINU`"', '"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"' (1)
starting dose:
5 mg PO once daily at bedtime; titrate to 10 mg/day after 4-6 weeks. Severe Alzheimer disease: may escalate to 23 mg/day. Adlarity patch: 5 or 10 mg/day applied weekly (1)
preparations:
Oral tablets 5, 10, 23 mg; ODT 5, 10 mg; Adlarity transdermal patch 5, 10 mg/day (weekly application) (1)
fda max:
23 mg/day (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
24 hours (once-daily dosing) (1)
halflife:
~70 hours (long, supports once-daily dosing without peak-trough variation)'"`UNIQ--ref-0000001B-QINU`"' (1)
bioavailability:
~100% (oral)'"`UNIQ--ref-0000001C-QINU`"' (1)
pregnancy:
Limited human data; rarely indicated in pregnancy given the patient population.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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