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Medicines > routes: transdermal & halflife: 2-3 hours (parent and active N-desethyl metabolite)'"`UNIQ--ref-000006E1-QINU`"'

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generic:
Oxybutynin (1)
brand:
Ditropan, Ditropan XL, Oxytrol (transdermal), Gelnique (gel) (1)
classes:
[[:Category:Antimuscarinics|Antimuscarinic]] (1) · [[:Category:Overactive_bladder_medications|Overactive bladder medication]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-000006DE-QINU`"', '"`UNIQ--vote-000006DF-QINU`"', '"`UNIQ--vote-000006E0-QINU`"' (1)
starting dose:
IR 5 mg PO BID-TID; ER 5-10 mg PO daily, titrate; transdermal patch 3.9 mg/d twice weekly (OTC) (1)
preparations:
5 mg IR tablets; 5, 10, 15 mg ER tablets; 5 mg/5 mL syrup; 3.9 mg/24 h transdermal patch (Oxytrol); 10% topical gel (1)
fda max:
30 mg/d (XL) typical (1)
routes: (Click arrow to add another value)
onset:
30-60 minutes (PO) (1)
duration:
IR: 6-10 hours; ER: 24 hours (1)
halflife: (Click arrow to add another value)
bioavailability:
~6% IR oral (substantial first-pass to active N-desethyl metabolite, which contributes most of the antimuscarinic adverse effects); transdermal bypasses first-pass and is better tolerated'"`UNIQ--ref-000006E2-QINU`"' (1)
pregnancy:
Limited data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC (transdermal patch in women) and [[USLegal:Prescription only|Rx-only]] (other forms) in US (1)
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