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Medicines > classes: [[GLP-1 receptor agonist]] · [[Antidiabetic medicines|Antidiabetic]] · Fc-fusion biologic & routes: Subcutaneous (abdomen

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generic:
Dulaglutide (1)
brand:
Trulicity (1)
classes: (Click arrow to add another value)
mechanism:
Long-acting agonist of the [[GLP-1 receptor]]; Fc-fusion construct. (1)
uses:
[[Type 2 diabetes mellitus]] · [[Cardiovascular risk reduction]] in T2DM (1)
starting dose:
0.75 mg SC weekly'"`UNIQ--ref-00000053-QINU`"' (1)
preparations:
Pre-filled single-dose pen: 0.75 / 1.5 / 3 / 4.5 mg'"`UNIQ--ref-00000054-QINU`"' (1)
fda max:
4.5 mg/wk SC'"`UNIQ--ref-00000055-QINU`"' (1)
routes: (Click arrow to add another value)
onset:
Glycemic effect within days; near-maximal HbA1c effect by 4 weeks at any given dose'"`UNIQ--ref-00000057-QINU`"' (1)
duration:
~7 days (weekly dosing)'"`UNIQ--ref-00000058-QINU`"' (1)
halflife:
~5 days (~120 h)'"`UNIQ--ref-00000059-QINU`"' (1)
bioavailability:
SC ~47%–65%'"`UNIQ--ref-0000005A-QINU`"' (1)
pregnancy:
Avoid. Discontinue at least 1 month before planned pregnancy. Animal data show embryofetal harm.'"`UNIQ--ref-0000005B-QINU`"' (1)
legal:
Rx-only;'"`UNIQ--ref-0000005C-QINU`"' not a controlled substance (1)

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