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Medicines > classes: [[:Category:Opioid analgesics|Opioid analgesic (full mu-agonist)]] & routes: SC

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generic:
Methadone (1)
brand:
Dolophine, Methadose, Diskets (oral dispersible tablets for OTPs) (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000004C-QINU`"', '"`UNIQ--vote-0000004D-QINU`"', '"`UNIQ--vote-0000004E-QINU`"' (1)
starting dose:
None (1)
preparations:
Tablets 5, 10, 40 mg (40 mg dispersible restricted to OTPs); oral concentrate 10 mg/mL; oral solution 1, 2, 10 mg/mL; injection 10 mg/mL (1)
fda max:
No formal hard ceiling; in MOUD maintenance, doses typically remain at or below 120 mg/day with higher doses reserved for documented under-treatment after careful clinical assessment (1)
routes: (Click arrow to add another value)
onset:
Oral analgesic effect 30-60 minutes; opioid-withdrawal suppression 30 minutes (oral); IV ~10 minutes (1)
duration:
Analgesic effect 4-8 hours (much shorter than half-life would suggest, due to receptor kinetics); MOUD effect (opioid withdrawal suppression) 24-36 hours per single daily dose (1)
halflife:
None (1)
bioavailability:
~70-85% (oral, high relative to other opioids) (1)
pregnancy:
None (1)
legal:
None (1)

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