Methamphetamine: Difference between revisions
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{{MedTemplate | {{MedTemplate | ||
| generic | | generic = Methamphetamine | ||
| brand | | brand = Desoxyn | ||
| structure | | structure = | ||
| classes | | classes = Psychostimulant, Amphetamine | ||
| | | uses = <vote slug="inattention-meth">Inattention</vote>, <vote slug="hyperactivity-meth">Hyperactivity</vote>, <vote slug="obesity-meth">Obesity</vote> | ||
| starting_dose = 5 mg PO | |||
| starting_dose | | preparations = Desoxyn 5 mg tabs | ||
| preparations | | fda_max = 25 mg/day (ADHD per Desoxyn label); 15 mg/day (obesity, short-term, per Desoxyn label) | ||
| fda_max = | | routes = Oral (prescribed) | ||
| routes | | onset = | ||
| onset | | duration = | ||
| duration | | halflife = | ||
| halflife | | bioavailability = | ||
| bioavailability | | pregnancy = Category C (per Desoxyn label) | ||
| pregnancy | | legal = Schedule II | ||
| legal | | mechanism = Monoamine releasing agent — TAAR1 agonism, VMAT2 substrate, DAT/NET reverse transport | ||
| intro | | intro = '''Methamphetamine''' is a CNS stimulant of the amphetamine class. It is FDA-approved (as '''Desoxyn''') for attention-deficit hyperactivity disorder and short-term management of obesity. It is a Schedule II controlled substance in the United States. | ||
| | | indications = <indication slug="adhd" title="ADHD in children, adolescents, and adults" author="MDElliottMD"/> | ||
| | <indication slug="obesity" title="Obesity (short-term)" author="MDElliottMD"/> | ||
| | | dosing = <titration slug="adhd-desoxyn" title="ADHD — per Desoxyn label" author="MDElliottMD"> | ||
| | Per the Desoxyn prescribing information, see the official label for current dosing guidance. | ||
| | </titration> | ||
| contraindications | | effects = | ||
| interactions | * <effect ref="attention" author="MDElliottMD"/> | ||
| pregnancy_details | * <effect ref="wakefulness" author="MDElliottMD"/> | ||
| monitoring | * <effect ref="motivation" author="MDElliottMD"/> | ||
| counseling | * <effect ref="euphoria" author="MDElliottMD"/> | ||
| anecdotes | * <effect ref="decreased-appetite" author="MDElliottMD"/> | ||
| seealso | * <effect ref="dry-mouth" author="MDElliottMD"/> | ||
| references | * <effect ref="hr-bp-elevation" author="MDElliottMD"/> | ||
* <effect ref="insomnia" author="MDElliottMD"/> | |||
* <effect ref="irritability" author="MDElliottMD"/> | |||
* <effect ref="anxiety" author="MDElliottMD"/> | |||
* <effect ref="headache" author="MDElliottMD"/> | |||
* <effect ref="weight-loss" author="MDElliottMD"/> | |||
* <effect ref="palpitations" author="MDElliottMD"/> | |||
* <effect ref="bruxism" author="MDElliottMD"/> | |||
* <effect ref="stereotypies" author="MDElliottMD"/> | |||
* <effect ref="agitation" author="MDElliottMD"/> | |||
* <effect ref="psychosis" author="MDElliottMD"/> | |||
* <effect ref="mania" author="MDElliottMD"/> | |||
* <effect ref="dependence" author="MDElliottMD"/> | |||
* <effect ref="tolerance" author="MDElliottMD"/> | |||
* <effect ref="cardiac-event" author="MDElliottMD"/> | |||
* <effect ref="seizure" author="MDElliottMD"/> | |||
* <effect ref="hyperthermia" author="MDElliottMD"/> | |||
* <effect ref="serotonin-syndrome" author="MDElliottMD"/> | |||
* <effect ref="withdrawal" author="MDElliottMD"/> | |||
| pk_absorption = | |||
| pk_distribution = | |||
| pk_metabolism = Hepatic metabolism includes N-demethylation to amphetamine (an active metabolite). | |||
| pk_elimination = Urinary elimination is pH-dependent. | |||
| pharmacodynamics = Methamphetamine acts at monoaminergic terminals as a releasing agent via TAAR1 agonism, VMAT2 substrate activity, and DAT/NET reverse transport. Secondary mechanisms include weak monoamine reuptake inhibition. | |||
| contraindications = Per Desoxyn label: | |||
* Advanced arteriosclerosis | |||
* Symptomatic cardiovascular disease | |||
* Moderate to severe hypertension | |||
* Hyperthyroidism | |||
* Known hypersensitivity to sympathomimetic amines | |||
* Glaucoma | |||
* Agitated states | |||
* History of drug abuse (per label wording) | |||
* Concurrent MAOI use, or within 14 days of MAOI discontinuation | |||
| interactions = * '''MAOIs''' — contraindicated (per label) | |||
* '''Acidifying agents''' — increase urinary clearance | |||
* '''Alkalinizing agents''' — decrease urinary clearance | |||
| pregnancy_details = Category C per Desoxyn label. | |||
| monitoring = | |||
| counseling = | |||
| anecdotes = | |||
| seealso = [[Mixed amphetamine salts]], [[Dextroamphetamine]], [[Lisdexamfetamine]], [[Methylphenidate]], [[Dexmethylphenidate]], [[Modafinil]] | |||
| references = <references/> | |||
}} | }} | ||
[[Category:Psychostimulants]] | [[Category:Psychostimulants]] | ||
Revision as of 06:09, 13 May 2026
Psychostimulant, Amphetamine
Methamphetamine
Desoxyn
Methamphetamine is a CNS stimulant of the amphetamine class. It is FDA-approved (as Desoxyn) for attention-deficit hyperactivity disorder and short-term management of obesity. It is a Schedule II controlled substance in the United States.
Methamphetamine acts at monoaminergic terminals as a releasing agent via TAAR1 agonism, VMAT2 substrate activity, and DAT/NET reverse transport. Secondary mechanisms include weak monoamine reuptake inhibition.
Mixed amphetamine salts, Dextroamphetamine, Lisdexamfetamine, Methylphenidate, Dexmethylphenidate, Modafinil
Experience
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Problems
<indication slug="adhd" title="ADHD in children, adolescents, and adults" author="MDElliottMD"/> <indication slug="obesity" title="Obesity (short-term)" author="MDElliottMD"/>
+ Add a problemTitration strategies
ADHD — per Desoxyn label0
Per the Desoxyn prescribing information, see the official label for current dosing guidance.
Effects
- Attention and focus no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Wakefulness no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Motivation and drive no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Mild euphoria no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Decreased appetite/Anorexia no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Dry mouth no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Elevated heart rate / blood pressure no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Insomnia no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Irritability no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Anxiety no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Headache no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Weight loss no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Palpitations no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Jaw clenching / bruxism no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Stereotyped behaviors no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Agitation no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Psychosis no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Mania no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Dependence / misuse no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Tolerance no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Serious cardiac event no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Seizure/Epileptic fit no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Hyperthermia no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Serotonin syndrome no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Withdrawal/Discontinuation Syndrome no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
Pharmacokinetics
Metabolism
Hepatic metabolism includes N-demethylation to amphetamine (an active metabolite).Elimination
Urinary elimination is pH-dependent.Pharmacodynamics
Interactions
- MAOIs — contraindicated (per label)
- Acidifying agents — increase urinary clearance
- Alkalinizing agents — decrease urinary clearance
Pregnancy and lactation
Relevant anecdote
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Relevant Literature
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See also
References
Pharmacy
Starting dose
5 mg PO
Preparations
Desoxyn 5 mg tabs
US FDA Max
25 mg/day (ADHD per Desoxyn label); 15 mg/day (obesity, short-term, per Desoxyn label)
Common uses
Classification(s)
Classes
Psychostimulant, Amphetamine
Pharmacology
Routes
Oral (prescribed)
Pregnancy
Category C (per Desoxyn label)
Legal status
Schedule II
Purported mechanism
Monoamine releasing agent — TAAR1 agonism, VMAT2 substrate, DAT/NET reverse transport