PDE5 Inhibitors: Difference between revisions
MDElliottMD (talk | contribs) Create PDE5 Inhibitors class category |
MDElliottMD (talk | contribs) Category taxonomy ship: add Category:Non-psychotropic medicines |
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== Class members == | == Class members == | ||
* [[Sildenafil]] (Viagra, Revatio) | * [[Sildenafil]] (Viagra, Revatio), first-in-class, FDA-approved 1998, half-life ~4 h | ||
* [[Vardenafil]] (Levitra, Staxyn) | * [[Vardenafil]] (Levitra, Staxyn), similar profile to sildenafil | ||
* [[Tadalafil]] (Cialis, Adcirca) | * [[Tadalafil]] (Cialis, Adcirca), long-acting, half-life ~17.5 h ("weekend pill") | ||
* [[Avanafil]] (Stendra) | * [[Avanafil]] (Stendra), newer, faster onset (~15 min), more selective | ||
== Universal warnings == | == Universal warnings == | ||
* '''Absolutely contraindicated with any nitrate''' | * '''Absolutely contraindicated with any nitrate''', life-threatening hypotension | ||
* Caution with alpha-blockers | * Caution with alpha-blockers, separate doses by ≥4 h | ||
* Avoid in patients where sexual activity itself is contraindicated by cardiovascular instability | * Avoid in patients where sexual activity itself is contraindicated by cardiovascular instability | ||
* All metabolized through CYP3A4 | * All metabolized through CYP3A4, strong inhibitors (azoles, protease inhibitors) raise levels | ||
[[Category:MedCategory]] | [[Category:MedCategory]] | ||
[[Category:Medicines]] | [[Category:Medicines]] | ||
[[Category:Pharmaceutical]] | |||
[[Category:Non-psychotropic medicines]] | |||
Latest revision as of 00:38, 22 May 2026
Phosphodiesterase type 5 (PDE5) inhibitors block the enzyme that degrades cyclic guanosine monophosphate (cGMP) in vascular smooth muscle. By preserving cGMP signaling downstream of nitric oxide, they enhance vasodilation in the corpus cavernosum (treating erectile dysfunction) and the pulmonary vasculature (treating pulmonary arterial hypertension).
Class members
- Sildenafil (Viagra, Revatio), first-in-class, FDA-approved 1998, half-life ~4 h
- Vardenafil (Levitra, Staxyn), similar profile to sildenafil
- Tadalafil (Cialis, Adcirca), long-acting, half-life ~17.5 h ("weekend pill")
- Avanafil (Stendra), newer, faster onset (~15 min), more selective
Universal warnings
- Absolutely contraindicated with any nitrate, life-threatening hypotension
- Caution with alpha-blockers, separate doses by ≥4 h
- Avoid in patients where sexual activity itself is contraindicated by cardiovascular instability
- All metabolized through CYP3A4, strong inhibitors (azoles, protease inhibitors) raise levels
Pages in category "PDE5 Inhibitors"
The following 4 pages are in this category, out of 4 total.