'"`UNIQ--vote-00000762-QINU`"' Largely renally cleared, hence the eGFR-tiered dosing. Rare but well-documented signals: acute pancreatitis (uncertain causal contribution), severe joint pain, and bullous pemphigoid (class effect, especially in older Asian patients)'"`UNIQ--ref-00000763-QINU`"'.
uses
String
'"`UNIQ--vote-00000764-QINU`"'
starting_dose
String
100 mg PO once daily (50 mg if CrCl 30-44; 25 mg if <30 or dialysis)
preparations
String
25, 50, 100 mg tablets; combination tablets with metformin
fda_max
String
100 mg/d
pill_id
Text
routes
List of String, delimiter: ,
Oral
onset
String
Postprandial glucose effect within days; HbA1c by 12 weeks
duration
String
24 hours
halflife
String
~12.4 hours'"`UNIQ--ref-00000765-QINU`"'
bioavailability
String
~87% (oral)'"`UNIQ--ref-00000766-QINU`"'
pregnancy
String
Limited data; switch to insulin where feasible.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup>
