View source for Insulin Degludec

{{MedTemplate
| generic           = Insulin degludec
| brand             = Tresiba
| structure         =
| classes           = [[:Category:Insulins|Insulin]], [[:Category:Ultra-long-acting_insulins|Ultra-long-acting insulin analog]], [[:Category:Basal_insulins|Basal insulin]]
| uses              = <vote slug="type1-diabetes-use">Type 1 diabetes mellitus</vote>, <vote slug="type2-diabetes-basal-use">Type 2 diabetes basal coverage</vote>
| starting_dose     = ~10 units SC at the same time daily, or 0.1-0.2 units/kg/d; titrate by fasting glucose
| preparations      = 100 U/mL (FlexTouch pen) and 200 U/mL (FlexTouch pen, higher-dose convenience)
| fda_max           = Titrated to glucose; no fixed ceiling
| pill_id           =
| routes            = Subcutaneous (never IV; not for use in insulin pumps)
| onset             = ~1 hour
| duration          = >42 hours per dose (effectively flat once at steady state)
| halflife          = ~25 hours apparent (functional duration well over 42 hours from multi-hexamer depot)<ref name="tresiba-label">FDA Prescribing Information, Tresiba (insulin degludec), Novo Nordisk, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/203314s022lbl.pdf</ref>
| bioavailability   = ~100% from subcutaneous depot
| pregnancy         = Insulin is the preferred glucose-lowering therapy in pregnancy; degludec has reassuring observational data.{{citation needed}}
| legal             = [[USLegal:Prescription only|Rx-only]] in US
| mechanism         = <vote slug="degludec-mech-claim">Insulin degludec self-assembles after subcutaneous injection into long multi-hexamer chains that slowly dissociate into monomers, providing a flat ultra-long-duration insulin profile (>42 hours) that supports forgiving dose-timing windows and lower nocturnal hypoglycemia rates than glargine in DEVOTE and SWITCH trials.</vote> Binds the same insulin receptor as endogenous insulin with comparable mitogenic-to-metabolic ratio<ref name="tresiba-label" />.
}}

== References ==
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